VALVULAR HEART DISEASE AND PULMONARY HYPERTENSION
Valve heart disease (VHD) and pulmonary hypertension (PH) represent important clinical subjects. In the Heart Valve Clinic we study novel insights into valve cell biology and tissue architecture, new mathematical models of valve geometry, 4-D flow mechanics, myocardial fibrosis and disarray and impact on prognosis of novel preventive and therapeutic measures. Technological developments for diagnosis and outcome prediction are pursued. PH associated or not with VHD is followed in the HAP Clinic, where we study genetic and humoral mechanisms involved in the pathogenesis, histopathology, flow mechanics, microvascular behaviour and heart lesions. The role of clinical data, imaging and biomarkers in outcome is studied.
To ensure the excellence of our project we involve a network of clinicians, imagiologists, cell biologists, physicists.
RESEARCH TEAM

Almeida, Ana, MD, PhD
GROUP LEADER
Ana G. Almeida graduated in Medicine from the Lisbon School of Medicine, Universidade de Lisboa, Portugal. She obtained her PhD in Medicine/Cardiology at the same institution in 2001. Since 2005, she has been Associate Professor, having achieved Habilitation (Aggregation) in 2010. She is a Senior Consultant of Cardiology at Santa Maria University Hospital – CHULN, Lisbon, where she chairs the Echocardiography and CMR/CT Units, as well as the Valve Heart Clinic.
She is currently Scientific Secretary of CCUL. At the European Society of Cardiology, she is a Fellow and Co-chair of the CMR Certification Board. She also serves as Chair of the Working Group on Nuclear Cardiology and CMR/CT of the Portuguese Society of Cardiology.
ORCID: 0000-0003-0360-4363
E-mail: anagalmeida@gmail.com

Brás-Rosário, Luís, MD, PhD
Researcher
Luís Brás-Rosário obtained his PhD in Medicine and Physiology with Distinction and Laudation in 2005, and his Medical Degree in 1988, both from the Lisbon School of Medicine, University of Lisbon, Portugal. He is currently an Assistant Professor of Cardiovascular Medicine and, since 2015, has served as Course Director (Regent) for the Instrumentation and Signal Transduction module of the Biomedical Engineering program.
Between 1995 and 1996, he was a Research Fellow in the Cardiovascular Department at Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Dr. Rosário is currently a Staff Cardiologist at the Coronary Care Unit, Cardiology Department, Santa Maria University Hospital – CHULN, E.P.E., Lisbon, Portugal. Since 2016, he has been a member of the TACTICS Group – International Alliance for Regenerative Therapies in Cardiovascular Syndromes.
He previously held positions as an Independent Postdoctoral Researcher at the Instituto Gulbenkian de Ciência, Oeiras, Portugal (2006–2011); and as a Research Fellow at the Autonomic Nervous System Unit, Lisbon School of Medicine, University of Lisbon (2002–2006). In 1995, he also worked as a Research Fellow at the Department of Physiology, Royal Free and University College Medical School, London, UK. He is a member of the American Physiological Society (Cardiovascular Section), an International Fellow of the American Heart Association (Council on Basic Cardiovascular Sciences), and a Fellow of the European Society of Cardiology. Within the ESC, he is an active member of the Working Groups on Myocardial Function, Cellular Biology of the Heart, and Cardiovascular Regenerative and Repair Medicine.
ORCID: 0000-0003-0014-1543
E-mail: lsrosario@medicina.ulisboa.pt
Co-Researcher in Structural and Heart Coronary Disease.

Sousa, Catarina, MD, PhD
Researcher
Catarina graduated in Medicine from the Faculty of Medicine, University of Lisbon, in 2004. In 2006, she began her Cardiology Residency at Hospital Pulido Valente, Lisbon. Her training included international rotations at the Intensive Care Unit of Saint Thomas’ Hospital and the Cardiothoracic Intensive Care Unit of the Royal Brompton Hospital, both in London.
In 2022, she completed her PhD in Cardiovascular Sciences at the Faculty of Medicine, University of Lisbon.
She is currently a Graduate Assistant in Cardiology at the Department of Heart and Vessels, CHULN, and also serves as an Invited Assistant at the Faculty of Medicine, University of Lisbon.
ORCID: 0000-0003-1709-6283
Email: catarina.sousa1@medicina.ulisboa.pt
Co-Researcher in Structure and Coronary Heart Disease

Fazendas, Paula, MD
PhD student
Paula Fazendas obtained her Medical Degree from the Lisbon School of Medicine, Universidade de Lisboa, graduating magna cum laude. She completed her Cardiology Fellowship at Hospital Garcia de Orta, Almada, with distinction (very good with excellence). In 2000–2001, she undertook a six-month fellowship in Stress, Transesophageal and Contrast Echocardiography at Mount Sinai Hospital, New York. Since 2017, she has been pursuing her PhD thesis at the Lisbon School of Medicine, Universidade de Lisboa.
She is currently Senior Cardiologist at Hospital Garcia de Orta, Almada. Previously, she served as Attending Cardiologist at Hospital Egas Moniz, Lisbon, and Hospital de Torres Vedras. She was certified by the United States Medical Licensing Examination (1995) and by the EACVI in Transthoracic Echocardiography (2014, recertified until 2024).
Her main research interests include stress echocardiography, exercise physiology, three-dimensional echocardiography, valvular heart disease, myocardial deformation imaging, left ventricle dyssynchrony, and coronary artery disease.
ORCID: 0000-0002-6216-4321
E-mail: pfazendas@hotmail.com

Ferreira, Ricardo, MD
PhD Student
Ricardo Ferreira graduated in Medicine from the Faculty of Medicine, University of Coimbra, and completed his specialization in Cardiothoracic Surgery at the Cardiothoracic Surgery Department of Santa Maria University Hospital – CHULN, E.P.E., Lisbon, Portugal. He currently works as a Specialist in Cardiothoracic Surgery at the same institution. He also serves as a Guest Assistant at the Faculty of Medical Sciences, University of Beira Interior.
His research activity has included collaboration with the Gulbenkian Institute of Science, focusing on the inflammatory response associated with cardiac surgery. His primary research interests focus on minimizing the surgical impact of cardiac and thoracic procedures through minimally invasive techniques and optimizing patient outcomes, particularly in valvular heart diseases.
ORCID: 0000-0003-0084-3916
E-mail: rmferreirast@gmail.com

Gonzalez, Filipe, MD
PhD Student
Filipe André Gonzalez is an Intensive Care Physician, recognized for his significant contributions to critical care research and clinical practice. He completed his Medical Degree in 2007, followed by specialization in Internal Medicine in 2014 and Intensive Care Medicine in 2019.
He holds the European Diploma in Echocardiography in Critical Care (EDEC) and currently serves as an EDEC Supervisor in Portugal. He is also an invited jury member for the European Diploma of Intensive Care (EDIC II), awarded by the European Society of Intensive Care Medicine (ESICM).
Filipe Gonzalez is a PhD student and Affiliated Professor at the Faculty of Medicine, University of Lisbon (FMUL), and a member of the Portuguese Society of Intensive Care (SPCI).
His research interests include diastology, septic cardiomyopathy, artificial intelligence in critical care, echocardiography, and lung ultrasound. He has authored and co-authored several publications in these fields.
In addition to his research, he is deeply involved in medical education, notably as course coordinator for POCUS, Advanced Echocardiography, and Hemodynamic Monitoring.
ORCID: 0000-0002-8539-1092
E-mail: filipeandregonzalez@gmail.com

Plácido, Rui, MD
PhD Student
Rui Plácido completed his Medical Degree in 2009 and his general internship in 2010. He finished his residency training in Cardiology in 2016 at the Cardiology Department of Santa Maria Hospital – CHULN, Lisbon, where he is currently a Specialist in Cardiology. His main clinical and research interests include cardiac imaging, heart failure, and pulmonary hypertension.
He teaches Cardiology at the Lisbon School of Medicine, Universidade de Lisboa. Dr. Plácido completed the Masterclass in Chronic Thromboembolic Pulmonary Hypertension (Papworth Hospital NHS Foundation Trust, 2016) and obtained the International Master Degree in Pulmonary Vascular Diseases certified by the University of Bologna. He also completed the 2nd Postgraduate Course in Heart Failure (ESC Heart Failure Association, ESC Heart Academy, Zurich Heart House, University Hospital of Zurich), earning a Certificate of Advanced Studies in Heart Failure.
He is certified in Adult Transthoracic Echocardiography and Adult Transesophageal Echocardiography by the European Association of Cardiovascular Imaging (EACVI).
ORCID: 1A11-7BF5-0D37
E-mail: placidorui@gmail.com

Lousada, Nuno, MD
Researcher
Nuno Lousada graduated in Medicine from the Lisbon School of Medicine, Universidade de Lisboa, Portugal, and obtained his specialization in Cardiology in 1988 at Santa Marta Hospital, Lisbon. Since 2000, he has been Cardiology Consultant at Pulido Valente Hospital, CHULN, Lisbon, where he currently chairs the Pulmonary Hypertension Program and the Heart Failure Ambulatory Clinic of the Cardiology Service, Heart and Vessels Department.
His main clinical and research interests include pulmonary hypertension, heart failure, and cardiac pacing.
E-mail: nunojlousada@netcabo.pt

Martins, Susana, MD
Researcher
Susana Martins graduated in Medicine from the Nova Medical School, Lisbon, and completed her specialization in Cardiology in 2000 at Santa Marta Hospital, Lisbon. She worked as a Cardiology Consultant from 2000 to 2005 at Nossa Senhora do Rosário Hospital, Barreiro, and Santa Marta Hospital, and since 2005 has been Consultant at Santa Maria University Hospital – CHULN, Lisbon. She is currently Co-Chair of the Pulmonary Hypertension Program.
In 2011, she obtained a Master’s Degree in Pulmonary Vascular Diseases from Bologna University Hospital under the supervision of Professor Nazareno Galiè. Since 2008, she has been Invited Assistant of Medicine/Cardiology at the Lisbon School of Medicine, Universidade de Lisboa.
Her main clinical and research interests include pulmonary hypertension, heart failure, and intensive care in Cardiology.
ORCID: 8516-A1A7-6873
E-mail: la63@sapo.pt

Nobre, Ângelo, MD
Researcher
ORCID: 0000-0002-0440-2707
E-mail: angelolucasnobre@gmail.com
Co-Researcher in Structural and Coronary Heart Disease

Carrilho-Ferreira, Pedro, MD
Researcher
Pedro Carrilho Ferreira graduated in Medicine from the Lisbon School of Medicine, Universidade de Lisboa, Portugal, in 2007. He is a Specialist in Cardiology with subspecialization in Interventional Cardiology. Since December 2014, he has been Consultant Cardiologist at the Department of Cardiology, Santa Maria Hospital – CHULN, Lisbon.
He has served as Scientific Advisor for the Integrated Master’s in Medicine at the Lisbon School of Medicine since 2011 and as Guest Assistant at the University Clinic of Cardiology of the same institution since 2013.
His main clinical and research interests include coronary heart disease, acute coronary syndromes, coronary angiography and percutaneous coronary intervention, intracoronary imaging, valvular heart disease, and percutaneous structural intervention.
ORCID: 0000-0003-2008-1496
E-mail: pcarrilhoferreira@gmail.com

Gonçalves, Susana, MSc
Researcher
Susana Gonçalves is currently working as a Senior Echocardiographer at department of Cardiology- Santa Maria University Hospital – CHULN, E.P.E., Lisbon, Portugal where she has been in this position since 2001. At present she is performing and reporting cardiac ultrasound tests (2D, M Mode, Doppler, Tissue Doppler, Strain and Strain Rate Imaging, Speckle tracking, 4D), and assisting the team in the performance of echocardiography stress tests, transoesophageal, and contrast echocardiography. Additionally, she is a supervisor of the echocardiography traineeships of cardiopulmonary technicians from Escola Superior de Tecnologia de Saúde de Lisboa since 2002 and participates in the training of the medical students from the Department of Cardiology, Santa Maria University Hospital – CHULN, E.P.E., Lisbon, Portugal.
Susana Gonçalves participated in several research projects at Department of Cardiology where she is also responsible for the coordination, monitoring and quality control of the cardiopulmonary technicians research work since 2008. She is certified by European Association of Echocardiography – European Society of Cardiology with the “Accreditation in Adult Transthoracic Echocardiography “since 2009.
ORCID: 0000-0002-0662-328X
E-mail: susanafdgpires@gmail.com
Co-Researcher in Paramyloidosis
SELECTED PUBLICATIONS
Enguita F, Almeida AG et al. Role of microRNAs on the left ventricle reverse remodeling after aortic valve replacement in patients with aortic valve stenosis. Focus Valv Heart Dis 2019; 1:8
Elvas L, Almeida AG et al. Calcium Identification and Scoring Based on Echocardiography. An Exploratory Study on Aortic Valve Stenosis. J Pers Med. 2021;11:598
Stepien E, Costa MC, et al. The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases. Acta Pharmacol Sin. 2018;39:1085
Rodrigues T, Silva BV, Plácido R et al. Comparison of 5 acute pulmonary embolism mortality risk scores in Int J Cardiol Heart Vasc. 2022;39:100984
Sousa C, Nogueira P, Pinto FJ. Insight into the epidemiology of infective endocarditis in Portugal: a contemporary nationwide study from 2010 to 2018. BMC Cardiovasc Disord. 2021;16;21:138
E-Book
Almeida AG, Pinto FJ, Enguita F. “Role of MicroRNA in the regulation of CV disease_on Focus remodelling”. Ed CCUL, 2019.